"Up until now, the president had very thoughtfully calibrated his remarks on Iran, but this was an uncharacteristic and egregious error," said Karim Sadjadpour, an Iran expert with the Carnegie Endowment for International Peace. "People are risking their lives and being slaughtered in the streets because they want fundamental change in the way Iran is governed. Our message to them shouldn't be that it doesn't make much difference to the United States."