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White Horse
Opinions differ on whether the first horseman, riding the white horse, represents Christ, the Antichrist, or the False Prophet, but the general consensus of biblical scholars is that he is the Antichrist.

One argument against this horseman representing Christ is that each horseman is released due the opening of a seal, and the seals represent God's curses upon the world, it is unlikely that the author would consider Christ's return as a curse. However, it could be conceived as a curse by those who oppose Him.

Red Horse
The second horseman, riding the red horse, is generally held to represent War. The red color of the second horse could mean bloody war, and the sword held by the rider could symbolize war and violence.

Black Horse
The third horseman, riding the black horse, is Famine. The black color of the third horse could be a symbol of death and famine. Its rider was holding a scale, which means scarcity of food, higher prices, and famine.

Pale Horse
The fourth horseman (on the pale, or sickly horse, which may be the source of the notion of "pestilence" as a separate horseman) is explicitly named Death. The pale greenish color of the fourth horse means fear, sickness, decay, and death. The imagery of the horses and riders is similar to a passage in Zechariah.